Molecular Modeling (add ref: Haxaire et al) results support the microscale and nanoscale patterns of HA fragments dehydrated on various surfaces. These patterns are also supported by X-ray data (There are x-ray results for HA helices (HYA1,,2HYA, 3HYA, 4HYA). The importance of water in altering the HA crystal matrix should not be underestimated.
Interact with various x-ray models of hyaluronic acid
SEM, AFM. TEM, and 3D LEXT Microscopy on dehydrated oligomers of hyaluronic acid show that the self-assembling hierarchical structures are consistent with X-ray structure data and molecular modeling.
The hyaluronic acid tree demonstrates how matrix engineering of tissue is possible. This pattern is an actual polyelectrolyte multilayer thin film of hyaluronic acid (~150K).
HA is a co-polymer of D-glucuronic acid and D-N-acetylglucosamine. HA sizes range from ~400 to ~20,000,000 g/mole
The polymeric repeat units of this carbohydrate scaffold can hydrate into nanofiber mesh and scaffold for the biomatrixgenesis of living creatures. Hyaluronic acid (HA) is a co-polymer of D-glucuronic acid and D-N-acetylglucosamine. Sizes of hyaluronic acid can range from ~400 to ~20,000,000 g/mole.
Contact information:Email Dr. Ray Turner at MajorRay@MajorRay.com
