Interact with various x-ray models of hyaluronic acid
Molecular Modeling (add ref: Haxaire et al) results support the microscale and nanoscale patterns of HA fragments dehydrated on various surfaces. These patterns are also supported by X-ray data (There are x-ray results for HA helices (HYA1,,2HYA, 3HYA, 4HYA). The importance of water in altering the HA crystal matrix should not be underestimated.
SEM, AFM. TEM, and 3D LEXT Microscopy on dehydrated oligomers of hyaluronic acid show that the self-assembling hierarchical structures are consistent with X-ray structure data and molecular modeling.
